Phytochemical and in vitro pharmacological evaluation of Phlomis pungens

Objective: This study aimed to investigate the in vitro wound healing, anti-inflammatory, antimicrobial and antioxidant activity of Phlomis pungens Willd. extract derived from aerial parts. Material Method: The phytochemical analysis was performed using GC-MS order identify volatile components bioactive Hex extract. healing P. evaluated based on antimicrobial, antioxidant, and, scratch studied. In addition, cytotoxicity also evaluated. Result Discussion: methanol depicted a 5-LOX inhibitory at 78.2µg/mL (IC50), while by DPPH radical provided an IC50=2.41mg/mL, ABTS showed IC50=3.32mg/mL, respectively. dose-dependently anti-inflammatory L-NAME significantly decreased LPS stimulated PGE2 production. According assay results, all treatments led increase cell migration rate with dose-dependent effect. Our findings suggested that may have role according test, it is thought its contributed. Further evaluations are ongoing confirm under vivo conditions.